Skip to main content
Fig. 4 | Cancer Cell International

Fig. 4

From: A humanized anti-CD26 monoclonal antibody inhibits cell growth of malignant mesothelioma via retarded G2/M cell cycle transition

Fig. 4

YS110 augments phosphorylation of p38MAPK and ERK1/2. a Activating phosohorylation of p38 (Thr180/Tyr182) and ERK1/2 (Thr202/Tyr204) were elevated by 24 h after treatment with YS110 while no substantial changes of whole p38 and ERK1/2 protein were observed. β-actin was used as an internal control. b G2/M arrest caused by YS110 treatment was reversed by ERK1/2 activation inhibitor U0126 (10 μM). A proportion (43.15 %) of G2/M was elevated in cells with YS110 treatment compared with in cells without YS110 (control, 37.05 %) and the proportion of G2/M decreased in cells with both YS110 and U0126 treatment (35.06 %). All experiments were performed in triplicate and a representative experiment is shown

Back to article page