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Fig. 7 | Cancer Cell International

Fig. 7

From: Induction of G1-phase cell cycle arrest and apoptosis pathway in MDA-MB-231 human breast cancer cells by sulfated polysaccharide extracted from Laurencia papillosa

Fig. 7

Proposed pathway of ASPE signaling in MDA-MB-231 cells. Diagram indicates: Induction of G1-phase cell cycle arrest and apoptosis in MDA-MB-231 cells. Low dose (10 µg/ml) of ASPE induce G1-phase arrest accompanied by up-regulation of Cip1/p21 and Kip1/p27 and down-regulation of cyclin D, and cyclin E transcripts and their related inhibitors Cdk2, Cdk4, and Cdk6.High dose (50 µg/ml) induce apoptosis in MDA-MB-231 cells and increase the expression of cleaved Caspase-3and Bax, and decrease the anti-apoptosis protein level of Bcl-2. Over-generation of reactive oxygen species ROS was also illustrated. Black triangles indicate up-regulation or down-regulation of gene/protein expression where the amplitude of triangle illustrates the fold change of expression

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