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Fig. 5 | Cancer Cell International

Fig. 5

From: Influence of TP53 and CDH1 genes in hepatocellular cancer spheroid formation and culture: a model system to understand cancer cell growth mechanics

Fig. 5

Live growth capture: spheroids in all 5 lines imaged at 1 and 3 days post seeding. The spheroid morphologies are distinct depending on the TP53 status. The TP53-wt cell lines, C3A and HepG2 form large spheroids with a smooth boundary edge. TP53-null cell line of Hep3B forms compact, intermediate-sized spheroids. The TP53-mutant cell lines, SNU-387 and SNU-475, form small sized spheroids with a rougher boundary edge. The size and shape patterns are consistent over the 10 day incubation period in multiple replicates

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