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Table 1 Patient characteristics

From: Failure of a patient-derived xenograft for brain tumor model prepared by implantation of tissue fragments

  Age Sex WHO grade Pathology MGMTa IDH1b P53 1p/19q Ki-67 L.I. EGFRg No. of implanted mice
Case #1 24 M IV GBMc Methylation Wild type Wild type Intact 5 % 0 3
Case #2 61 M IV GBMc Unmethylation Wild type 5 % LOH/intact Focal 20–30 % and overall 5 % 3+ 3
Case #3 24 M IV GBMc Unmethylation Wild type 80–90 % Intact 50 % 2–3+ 3
Case #4 50 M IV GBMc Methylation Mutation NA NA NA NA 3
Case #5 62 F IV GBMc Methylation Wild type Wild type Intact 5–6 % 3+ 4
Case #6 11 M IV GBMc Unmethylation Wild type 50–60 % Intact 70–80 % 0 3
Case #7 26 M IV GBMc Unmethylation Wild type 50–60 % LOHf 40–50 % 2–3+ 3
Case #8 1.3 M IV PNETd NAe NA NA NA 50–60 % NA 3
  1. a O(6)-methylguanine methyltransferase
  2. b Isocitrate dehydrogenase 1
  3. c Glioblastoma
  4. d Primitive neuroectodermal tumor
  5. e Non-available
  6. f Loss of heterozygosity
  7. g Epidermal growth factor receptor amplification