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Table 1 Patient characteristics

From: Failure of a patient-derived xenograft for brain tumor model prepared by implantation of tissue fragments

 

Age

Sex

WHO grade

Pathology

MGMTa

IDH1b

P53

1p/19q

Ki-67 L.I.

EGFRg

No. of implanted mice

Case #1

24

M

IV

GBMc

Methylation

Wild type

Wild type

Intact

5 %

0

3

Case #2

61

M

IV

GBMc

Unmethylation

Wild type

5 %

LOH/intact

Focal 20–30 % and overall 5 %

3+

3

Case #3

24

M

IV

GBMc

Unmethylation

Wild type

80–90 %

Intact

50 %

2–3+

3

Case #4

50

M

IV

GBMc

Methylation

Mutation

NA

NA

NA

NA

3

Case #5

62

F

IV

GBMc

Methylation

Wild type

Wild type

Intact

5–6 %

3+

4

Case #6

11

M

IV

GBMc

Unmethylation

Wild type

50–60 %

Intact

70–80 %

0

3

Case #7

26

M

IV

GBMc

Unmethylation

Wild type

50–60 %

LOHf

40–50 %

2–3+

3

Case #8

1.3

M

IV

PNETd

NAe

NA

NA

NA

50–60 %

NA

3

  1. a O(6)-methylguanine methyltransferase
  2. b Isocitrate dehydrogenase 1
  3. c Glioblastoma
  4. d Primitive neuroectodermal tumor
  5. e Non-available
  6. f Loss of heterozygosity
  7. g Epidermal growth factor receptor amplification