Fig. 1From: The availability of the embryonic TGF-β protein Nodal is dynamically regulated during glioblastoma multiforme tumorigenesisNodal protein intracellular distribution depends on GBM differentitation status. a Nodal immunostaining was symmetrically distributed in the cytoplasm of OB1 stem cells. b Optical slices projected on the YZ axis showing a virtual reconstruction of the cell seen in “a” (asterisk). Nodal was localized to vesicle-like particles (arrow). c In GBM011 cells, Nodal immunostaining was found in a rare population of cells and was asymmetrically localized to a perinuclear region. Vesicle-like particle were also observed (arrow)Back to article page