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Table 2 Associations between CD44 expression and OS of HCC grouped by selected factors

From: Prognostic value of CD44 expression in patients with hepatocellular carcinoma: meta-analysis

Stratified analysis Studies Odds ratio Model Heterogeneity
OR (95 % CI) POR I2 (%) P
OS 15 1.49 (1.26–1.76) <0.00001 Random 74 <0.00001
Method
 IHC 13 1.48 (1.22–1.78) <0.0001 Random 76 <0.00001
 RT-PCR 2 1.64 (1.32–2.04) <0.0001 Fixed 0 0.99
Cut off
 >10 % 3 1.63 (1.05–2.54) 0.03 Random 55 0.11
 ≤10 % 10 1.45 (1.17–1.80) 0.0007 Random 80 <0.00001
 Median 2 1.64 (1.32–2.04) <0.0001 Fixed 0 0.99
Sample size
 >50 11 1.38 (1.17–1.64) 0.0002 Random 75 <0.0001
 ≤50 4 2.26 (1.64–3.12) <0.00001 Fixed 30 0.23
Follow-up(m)
 >60 8 1.53 (1.22–1.92) 0.0002 Random 74 0.0004
 ≤60 7 1.46 (1.12–1.90) 0.005 Random 76 0.0004
Subtypes of the CD44 family
 CD44 4 1.35 (1.16–1.56) 0.0001 Fixed 24 0.27
 CD44v6 6 1.51 (1.11–2.05) 0.008 Random 86 <0.00001
 CD44s 5 1.59 (1.10–2.29) 0.01 Random 74 0.004
  1. POR P value for odds ratio