Table 2 Associations between CD44 expression and OS of HCC grouped by selected factors
From: Prognostic value of CD44 expression in patients with hepatocellular carcinoma: meta-analysis
Stratified analysis | Studies | Odds ratio | Model | Heterogeneity | ||
|---|---|---|---|---|---|---|
OR (95 % CI) | POR | I2 (%) | P | |||
OS | 15 | 1.49 (1.26–1.76) | <0.00001 | Random | 74 | <0.00001 |
Method | ||||||
IHC | 13 | 1.48 (1.22–1.78) | <0.0001 | Random | 76 | <0.00001 |
RT-PCR | 2 | 1.64 (1.32–2.04) | <0.0001 | Fixed | 0 | 0.99 |
Cut off | ||||||
>10 % | 3 | 1.63 (1.05–2.54) | 0.03 | Random | 55 | 0.11 |
≤10 % | 10 | 1.45 (1.17–1.80) | 0.0007 | Random | 80 | <0.00001 |
Median | 2 | 1.64 (1.32–2.04) | <0.0001 | Fixed | 0 | 0.99 |
Sample size | ||||||
>50 | 11 | 1.38 (1.17–1.64) | 0.0002 | Random | 75 | <0.0001 |
≤50 | 4 | 2.26 (1.64–3.12) | <0.00001 | Fixed | 30 | 0.23 |
Follow-up(m) | ||||||
>60 | 8 | 1.53 (1.22–1.92) | 0.0002 | Random | 74 | 0.0004 |
≤60 | 7 | 1.46 (1.12–1.90) | 0.005 | Random | 76 | 0.0004 |
Subtypes of the CD44 family | ||||||
CD44 | 4 | 1.35 (1.16–1.56) | 0.0001 | Fixed | 24 | 0.27 |
CD44v6 | 6 | 1.51 (1.11–2.05) | 0.008 | Random | 86 | <0.00001 |
CD44s | 5 | 1.59 (1.10–2.29) | 0.01 | Random | 74 | 0.004 |