Fig. 4
Multiple functions of Survivin. Survivin overexpression suppresses apoptosis or induces abnormal cell division, promotes tumour angiogenesis or metastasis of tumour cells. Survivin may also be expressed extracellularly in form of exosomes and exacerbate disease. Survivin expression may also influence cancer stem cell fate. Therapeutic targeting of Survivin through Survivin inhibitors may serve to block Survivin expression and induce removal of cancer cells. Immunotherapy with Survivin will boost generation of immune response against Survivin by generating Survivin specific CTLs