Table 1 Genotyping result of Sequenom MassARRAY (control n = 760)

rs2746533-PADI2

 Allele

C T

C T

C T

C T

C T

C T

C T

C T

 Case (freq)

5 (0.004) 1251 (0.996)

1 (0.003) 315 (0.997)

2 (0.004) 462 (0.996)

0 (0.000) 974 (1.000)

1 (0.003) 305 (0.997)

3 (0.003) 1003 (0.997)

0 (0.000) 214 (1.000)

3 (0.011) 265 (0.989)

 Control (freq)

5 (0.004) 1111 (0.996)

5 (0.004) 1111 (0.996)

5 (0.004) 1111 (0.996)

5 (0.004) 1111 (0.996)

5 (0.004) 1111 (0.996)

5 (0.004) 1111 (0.996)

5 (0.004) 1111 (0.996)

5 (0.004) 1111 (0.996)

 Odds ratio (% 95 CI)

0.888090 (0.256423–3.075787)

0.705397 (0.082109–6.060061)

0.961905 (0.185950–4.975867)

0.728525 (0.084793–6.259333)

0.664606 (0.158423–2.788111)

2.515472 (0.597393–10.592010)

 Fisher’s p value

0.851382

0.749245

0.963054

0.036536

0.771955

0.573935

0.326631

0.19301

 Genotype

C/T T/T

C/T T/T

C/T T/T

C/T T/T

C/T T/T

C/T T/T

C/T T/T

C/T T/T

 Case (freq)

5 (0.008) 623 (0.992)

1 (0.006) 157 (0.994)

2 (0.009) 230 (0.991)

0 (0.000) 487 (1.000)

1 (0.007) 152 (0.993)

3 (0.006) 500 (0.994)

0 (0.000) 107 (1.000)

3 (0.022) 131 (0.978)

 Control (freq)

5 (0.009) 553 (0.991)

5 (0.009) 553 (0.991)

5 (0.009) 553 (0.991)

5 (0.009) 553 (0.991)

5 (0.009) 553 (0.991)

5 (0.009) 553 (0.991)

5 (0.009) 553 (0.991)

5 (0.009) 553 (0.991)

 Odds ratio (% 95 CI)

0.887640 (0.255616–3.082381)

0.704459 (0.081700–6.074199)

0.961739 (0.185248–4.992999)

0.663600 (0.157779–2.791021)

2.532825 (0.597703–10.733088)

 Fisher’s p value

0.85107

0.748734

0.962971

0.036311

0.771484

0.573208

0.325716

0.191714

 HWE for case (df = 1)

0.920197

0.968156

0.947409

1

0.967636

0.946498

1

0.895718

 HWE for control (df = 1)

0.915315

0.915315

0.915315

0.915315

0.915315

0.915315

0.915315

0.915315

rs2076616-PADI2

 Allele

C T

C T

C T

C T

C T

C T

C T

C T

 Case (freq)

744 (0.594) 508 (0.406)

242 (0.602) 160 (0.398)

433 (0.568) 329 (0.432)

585 (0.603) 385 (0.397)

187 (0.607) 121 (0.393)

594 (0.590) 412 (0.410)

125 (0.584) 89 (0.416)

195 (0.606) 127 (0.394)

 Control (freq)

863 (0.569) 655 (0.431)

863 (0.569) 655 (0.431)

863 (0.569) 655 (0.431)

863 (0.569) 655 (0.431)

863 (0.569) 655 (0.431)

863 (0.569) 655 (0.431)

863 (0.569) 655 (0.431)

863 (0.569) 655 (0.431)

 Odds ratio (% 95 CI)

1.111577 (0.955026–1.293791)

1.147958 (0.917529–1.436256)

0.998901 (0.837961–1.190752)

1.153256 (0.978920–1.358640)

1.172970 (0.913311–1.506450)

1.094258 (0.930993–1.286154)

1.065984 (0.797481–1.424888)

1.165363 (0.911687–1.489624)

 Fisher’s p value

0.171997

0.227272

0.990214

0.088135

0.21118

0.274552

0.666036

0.221572

 Genotype

C/C C/T T/T

C/C C/T T/T

C/C C/T T/T

C/C C/T T/T

C/C C/T T/T

C/C C/T T/T

C/C C/T T/T

C/C C/T T/T

 Case (freq)

211 (0.337) 322 (0.514) 93 (0.149)

73 (0.363) 96 (0.478) 32 (0.159)

121 (0.318) 191 (0.501) 69 (0.181)

160 (0.330) 265 (0.546) 60 (0.124)

57 (0.370) 73 (0.474) 24 (0.156)

175 (0.348) 244 (0.485) 84 (0.167)

31 (0.290) 63 (0.589) 13 (0.121)

62 (0.385) 71 (0.441) 28 (0.174)

 Control (freq)

246 (0.324) 371 (0.489) 142 (0.187)

246 (0.324) 371 (0.489) 142 (0.187)

246 (0.324) 371 (0.489) 142 (0.187)

246 (0.324) 371 (0.489) 142 (0.187)

246 (0.324) 371 (0.489) 142 (0.187)

246 (0.324) 371 (0.489) 142 (0.187)

246 (0.324) 371 (0.489) 142 (0.187)

246 (0.324) 371 (0.489) 142 (0.187)

 Odds ratio (% 95 CI)

  Fisher’s p value

0.163453

0.483706

0.921641

0.009749

0.458051

0.547721

0.107007

0.32765

  HWE for case (df = 1)

0.095379

0.962603

0.672532

0.001867

0.937468

0.946205

0.028433

0.329539

  HWE for control (df = 1)

0.918961

0.918961

0.918961

0.918961

0.918961

0.918961

0.918961

0.918961

rs10788656-PADI2

 Allele

C G

C G

C G

C G

C G

C G

C G

C G

 Case (freq)

1119 (0.894) 133 (0.106)

351 (0.869) 53 (0.131)

655 (0.862) 105 (0.138)

859 (0.886) 111 (0.114)

283 (0.919) 25 (0.081)

888 (0.883) 118 (0.117)

190 (0.888) 24 (0.112)

280 (0.870) 42 (0.130)

 Control (freq)

1380 (0.909) 138 (0.091)

1380 (0.909) 138 (0.091)

1380 (0.909) 138 (0.091)

1380 (0.909) 138 (0.091)

1380 (0.909) 138 (0.091)

1380 (0.909) 138 (0.091)

1380 (0.909) 138 (0.091)

1380 (0.909) 138 (0.091)

 Odds ratio (% 95 CI)

0.841353 (0.654673–1.081266)

0.662264 (0.472460–0.928320)

0.623810 (0.476051–0.817430)

0.773874 (0.594307–1.007696)

1.132000 (0.725548–1.766147)

0.752542 (0.580357–0.975814)

0.791667 (0.500143–1.253114)

0.666667 (0.461171–0.963731)

 Fisher’s p value

0.176816

0.016208

0.000577

0.05659

0.584658

0.031606

0.317835

0.030167

 Genotype

C/C C/G G/G

C/C C/G G/G

C/C C/G G/G

C/C C/G G/G

C/C C/G G/G

C/C C/G G/G

C/C C/G G/G

C/C C/G G/G

 Case (freq)

494 (0.789) 131 (0.209) 1 (0.002)

152 (0.752) 47 (0.233) 3 (0.015)

279 (0.734) 97 (0.255) 4 (0.011)

382 (0.788) 95 (0.196) 8 (0.016)

129 (0.838) 25 (0.162) 0 (0.000)

394 (0.783) 100 (0.199) 9 (0.018)

84 (0.785) 22 (0.206) 1 (0.009)

122 (0.758) 36 (0.224) 3 (0.019)

 Control (freq)

628 (0.827) 124 (0.163) 7 (0.009)

628 (0.827) 124 (0.163) 7 (0.009)

628 (0.827) 124 (0.163) 7 (0.009)

628 (0.827) 124 (0.163) 7 (0.009)

628 (0.827) 124 (0.163) 7 (0.009)

628 (0.827) 124 (0.163) 7 (0.009)

628 (0.827) 124 (0.163) 7 (0.009)

628 (0.827) 124 (0.163) 7 (0.009)

 Odds ratio (% 95 CI)

  Fisher’s p value

0.018396

0.052554

0.001004

0.161302

0.487441

0.097391

0.549667

0.098232

  HWE for case (df = 1)

0.010705

0.768654

0.161016

0.459996

0.272946

0.370499

0.737085

0.856144

  HWE for control (df = 1)

0.749415

0.749415

0.749415

0.749415

0.749415

0.749415

0.749415

0.749415