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Fig. 3 | Cancer Cell International

Fig. 3

From: Selected polyphenols potentiate the apoptotic efficacy of glycolytic inhibitors in human acute myeloid leukemia cell lines. Regulation by protein kinase activities

Fig. 3

Effect lonidamine, glucose deprivation, and polyphenols on proliferation and apoptosis. (ac) Frequency of apoptosis upon incubation of HL60 cells with the indicated concentrations (μM) of a Quer, b Cur, c Gen, and lonidamine (Lon), alone and in combination. (df) The bar charts indicate (d) the relative cell number, as an estimation of proliferation rate, (e) apoptosis, and (f) free PI uptake upon 24 h culture of HL60 cells in medium lacking glucose (Glu−), with or without Quer. Values in (d) are expressed in relation to cultures maintained in complete (glucose-containing) medium. In all cases, treatments with 2-DG alone or with Quer plus 2-DG are included as controls. Symbol (&) mean significant differences in relation to Cont. Other conditions, including pre-incubation with polyphenols in the combined treatments and other symbols used in statistical analysis, were as in Fig. 1

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