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Fig. 7 | Cancer Cell International

Fig. 7

From: Selected polyphenols potentiate the apoptotic efficacy of glycolytic inhibitors in human acute myeloid leukemia cell lines. Regulation by protein kinase activities

Fig. 7

Effect of protein kinase inhibitors. The figure shows the capacity of protein kinase inhibitors to modulate apoptosis generation in HL60 cells by treatment with the indicated concentrations of Quer (μM) and 2-DG (mM), alone or the combination. As a rule, the kinase inhibitors were applied 1 h before the other drugs. a Effects of the PI3 K inhibitor LY294002 (LY, 30 μM) and the Akt inhibitor triciribine (Tric, 10 μM). b Effects of the MEK/ERK inhibitors U0126 (U, 5 μM) and PD98059 (PD, 20 μM). c Effects of the GSK-3 inhibitor SB216763 (SB21, 10 μM). d Effects of the p38-MAPK inhibitor SB203580 (SB20, 10 μM). Results are the mean ± S.D. of at least four determinations. Other conditions, including pre-incubation with Quer in the combined treatments and symbols used in statistical analysis, were as in Fig. 1

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