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Fig. 1 | Cancer Cell International

Fig. 1

From: Robo3A and Robo3B expression is regulated via alternative promoters and mRNA stability

Fig. 1

a Schematic structure of Robo3A and Robo3B. Robo3B lacks exon 1 of Robo3A and starts from an alternative transcription start site (TSS) in intron 1 of the NCBI reference gene, Robo3A [7]. The first 53 amino acids of Robo3A are not part of Robo3B. The Robo3B protein contains 33 amino acids, not being found in the Robo3A isoform (ENSEMBL). b Robo3B mRNA expression relative to Robo3A mRNA expression, determined via qRT-PCR. The majority of normal tissues exhibit a higher Robo3B expression compared to Robo3A, except all tissues of the brain and a few others

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