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Table 1 Demographic and clinical characteristics of patients with WHO grade IV glioma

From: Success of tumorsphere isolation from WHO grade IV gliomas does not correlate with the weight of fresh tumor specimens: an immunohistochemical characterization of tumorsphere differentiation

Characteristics TS culture positive (n = 18) TS culture negative (n = 17) P value*
Age (years) 62.6 ± 10.7 55.5 ± 12.9 0.088
Sex (M:F) 10:8 10:7 0.845
Pathological diagnosis    >0.999
 GBM 14 (77.8 %) 15 (88.2 %)  
 GBMO 2 (11.1 %) 1 (5.9 %)  
 Gliosarcoma 2 (11.1 %) 1 (5.9 %)  
Type    >0.999
 Primary 16 (88.9 %) 15 (88.2 %)  
 Recurrent 2 (11.1 %) 2 (11.8 %)  
Molecular markers
 IDH1
  Wild type 18 (100 %) 17 (100 %)  
  Mutation 0 0  
1p19q    >0.999
 No deletion 16 (88.9 %) 15 (88.2 %)  
 Codeletion 2 (11.1 %) 2 (11.8 %)  
MGMT promotor    0.358
 Unmethylated 10 (55.6 %) 12 (70.6 %)  
 Methylated 8 (44.4 %) 5 (29.4 %)  
P53 mutation    0.443
 Wild type 3 (16.7 %) 5 (29.4 %)  
 Positive by IHC 15 (84.3 %) 12 (70.6 %)  
EGFR mutation    0.193
 Wild type 8 (44.4 %) 4 (23.5 %)  
 Positive by FISH 10 (55.6 %) 13 (76.5 %)  
  1. * By Independent two-sample t test for continuous variables and Chi square test (or Fisher’s exact test) for categorical variables