Table 1 Demographic and clinical characteristics of patients with WHO grade IV glioma
Characteristics | TS culture positive (n = 18) | TS culture negative (n = 17) | P value* |
|---|---|---|---|
Age (years) | 62.6 ± 10.7 | 55.5 ± 12.9 | 0.088 |
Sex (M:F) | 10:8 | 10:7 | 0.845 |
Pathological diagnosis | >0.999 | ||
GBM | 14 (77.8 %) | 15 (88.2 %) | |
GBMO | 2 (11.1 %) | 1 (5.9 %) | |
Gliosarcoma | 2 (11.1 %) | 1 (5.9 %) | |
Type | >0.999 | ||
Primary | 16 (88.9 %) | 15 (88.2 %) | |
Recurrent | 2 (11.1 %) | 2 (11.8 %) | |
Molecular markers | |||
IDH1 | |||
Wild type | 18 (100 %) | 17 (100 %) | |
Mutation | 0 | 0 | |
1p19q | >0.999 | ||
No deletion | 16 (88.9 %) | 15 (88.2 %) | |
Codeletion | 2 (11.1 %) | 2 (11.8 %) | |
MGMT promotor | 0.358 | ||
Unmethylated | 10 (55.6 %) | 12 (70.6 %) | |
Methylated | 8 (44.4 %) | 5 (29.4 %) | |
P53 mutation | 0.443 | ||
Wild type | 3 (16.7 %) | 5 (29.4 %) | |
Positive by IHC | 15 (84.3 %) | 12 (70.6 %) | |
EGFR mutation | 0.193 | ||
Wild type | 8 (44.4 %) | 4 (23.5 %) | |
Positive by FISH | 10 (55.6 %) | 13 (76.5 %) | |