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Table 2 Relationship between the expression of TRAF6 and clinicopathological features in HCC

From: Relationship between TRAF6 and deterioration of HCC: an immunohistochemical and in vitro study

Clinicopathological parameters n TRAF6 negative n (%) TRAF6 positive n (%) Z P Correlation
r p
Age
<50 67 37 (55.2) 30 (44.8) −1.032 0.302   
≥50 104 49 (47.1) 55 (52.9)
Gender
Male 153 76 (49.7) 77 (50.3) −0.471 0.638 −0.036 0.639
Female 18 10 (55.6) 8 (44.4)
Differentiation
High 20 14 (70.0) 6 (30.0) 3.685* 0.158 0.116 0.130
Moderate 98 48 (49.0) 50 (51.0)
Low 53 24 (45.3) 29 (54.7)
Size
<5 cm 58 34 (58.6) 24 (41.4) −1.556 0.120 0.119 0.120
≥5 cm 113 52 (46.0) 61 (54.0)
Tumor nodes
Single 68 29 (42.6) 39 (57.4) −0.370 0.711 −0.033 0.713
Multiple 61 28 (45.9) 33 (54.1)
Metastasis
90 52 (57.8) 38 (42.2) −2.058 0.040 0.158 0.039
+ 81 34 (42.0) 47 (58.0)
Clinical TNM stage
I ~ II 48 29 (60.4) 19 (39.6) −1.649 0.099 0.126 0.099
III ~ IV 123 57 (46.3) 66 (53.7)
Portal vein tumor embolus
84 37 (44.0) 47 (56.0) −0.043 0.966 −0.004 0.966
+ 45 20 (44.4) 25 (55.6)
Vaso-invasion
77 34 (44.2) 43 (55.8) −0.008 0.993 0.000 0.993
+ 52 23 (44.2) 29 (55.8)
Tumor capsular infiltration
Yes 61 27 (44.3) 34 (55.7) −0.016 0.987 0.001 0.987
No 68 30 (44.1) 38 (55.9)
HCV
87 40 (46.0) 47 (54.0) −0.587 0.557 0.052 0.559
+ 42 17 (40.5) 25 (59.5)
HBV
24 9 (37.5) 15 (62.5) −0.728 0.466 −0.064 0.469
+ 105 48 (45.7) 57 (54.3)
AFP
56 24 (42.9) 32 (57.1) −0.748 0.455 0.072 0.457
+ 54 27 (50.0) 27 (50.0)
Cirrhosis
74 33 (44.6) 41 (55.4) −1.298 0.194 0.100 0.195
+ 97 53 (54.6) 44 (45.4)
nm23
25 7 (28.0) 18 (72.0) −1.808 0.071 −0.160 0.070
+ 104 50 (48.1) 54 (51.9)
P53
54 25 (46.3) 29 (53.7) −0.408 0.683 0.036 0.685
+ 75 32 (42.7) 43 (57.3)
P21
84 36 (42.9) 48 (57.1) −0.414 0.679 −0.037 0.681
+ 45 21 (46.7) 24 (53.3)
VEGF
33 13 (39.4) 20 (60.6) −0.640 0.522 −0.057 0.524
  + 96 44 (45.8) 52 (54.2)
Ki-67 LI
Low 62 26 (41.9) 36 (58.1) −0.803 0.422 −0.073 0.424
High 61 30 (49.2) 31 (50.8)
MVD
Low 61 19 (31.1) 42 (68.9) −2.813 0.005 −0.249 0.004
High 68 38 (55.9) 30 (44.1)
  1. * Kruskal–Wallis H test; − Negative; + Positive; LI label index; MVD micro-vessel density