Table 2 Relationship between the expression of TRAF6 and clinicopathological features in HCC
From: Relationship between TRAF6 and deterioration of HCC: an immunohistochemical and in vitro study
Clinicopathological parameters | n | TRAF6 negative n (%) | TRAF6 positive n (%) | Z | P | Correlation | ||
|---|---|---|---|---|---|---|---|---|
r | p | |||||||
Age | ||||||||
<50 | 67 | 37 (55.2) | 30 (44.8) | −1.032 | 0.302 |  |  | |
≥50 | 104 | 49 (47.1) | 55 (52.9) | |||||
Gender | ||||||||
Male | 153 | 76 (49.7) | 77 (50.3) | −0.471 | 0.638 | −0.036 | 0.639 | |
Female | 18 | 10 (55.6) | 8 (44.4) | |||||
Differentiation | ||||||||
High | 20 | 14 (70.0) | 6 (30.0) | 3.685* | 0.158 | 0.116 | 0.130 | |
Moderate | 98 | 48 (49.0) | 50 (51.0) | |||||
Low | 53 | 24 (45.3) | 29 (54.7) | |||||
Size | ||||||||
<5 cm | 58 | 34 (58.6) | 24 (41.4) | −1.556 | 0.120 | 0.119 | 0.120 | |
≥5 cm | 113 | 52 (46.0) | 61 (54.0) | |||||
Tumor nodes | ||||||||
Single | 68 | 29 (42.6) | 39 (57.4) | −0.370 | 0.711 | −0.033 | 0.713 | |
Multiple | 61 | 28 (45.9) | 33 (54.1) | |||||
Metastasis | ||||||||
– | 90 | 52 (57.8) | 38 (42.2) | −2.058 | 0.040 | 0.158 | 0.039 | |
+ | 81 | 34 (42.0) | 47 (58.0) | |||||
Clinical TNM stage | ||||||||
I ~ II | 48 | 29 (60.4) | 19 (39.6) | −1.649 | 0.099 | 0.126 | 0.099 | |
IIIÂ ~Â IV | 123 | 57 (46.3) | 66 (53.7) | |||||
Portal vein tumor embolus | ||||||||
– | 84 | 37 (44.0) | 47 (56.0) | −0.043 | 0.966 | −0.004 | 0.966 | |
+ | 45 | 20 (44.4) | 25 (55.6) | |||||
Vaso-invasion | ||||||||
– | 77 | 34 (44.2) | 43 (55.8) | −0.008 | 0.993 | 0.000 | 0.993 | |
+ | 52 | 23 (44.2) | 29 (55.8) | |||||
Tumor capsular infiltration | ||||||||
Yes | 61 | 27 (44.3) | 34 (55.7) | −0.016 | 0.987 | 0.001 | 0.987 | |
No | 68 | 30 (44.1) | 38 (55.9) | |||||
HCV | ||||||||
– | 87 | 40 (46.0) | 47 (54.0) | −0.587 | 0.557 | 0.052 | 0.559 | |
+ | 42 | 17 (40.5) | 25 (59.5) | |||||
HBV | ||||||||
– | 24 | 9 (37.5) | 15 (62.5) | −0.728 | 0.466 | −0.064 | 0.469 | |
+ | 105 | 48 (45.7) | 57 (54.3) | |||||
AFP | ||||||||
– | 56 | 24 (42.9) | 32 (57.1) | −0.748 | 0.455 | 0.072 | 0.457 | |
+ | 54 | 27 (50.0) | 27 (50.0) | |||||
Cirrhosis | ||||||||
– | 74 | 33 (44.6) | 41 (55.4) | −1.298 | 0.194 | 0.100 | 0.195 | |
+ | 97 | 53 (54.6) | 44 (45.4) | |||||
nm23 | ||||||||
– | 25 | 7 (28.0) | 18 (72.0) | −1.808 | 0.071 | −0.160 | 0.070 | |
+ | 104 | 50 (48.1) | 54 (51.9) | |||||
P53 | ||||||||
– | 54 | 25 (46.3) | 29 (53.7) | −0.408 | 0.683 | 0.036 | 0.685 | |
+ | 75 | 32 (42.7) | 43 (57.3) | |||||
P21 | ||||||||
– | 84 | 36 (42.9) | 48 (57.1) | −0.414 | 0.679 | −0.037 | 0.681 | |
+ | 45 | 21 (46.7) | 24 (53.3) | |||||
VEGF | ||||||||
– | 33 | 13 (39.4) | 20 (60.6) | −0.640 | 0.522 | −0.057 | 0.524 | |
| Â | + | 96 | 44 (45.8) | 52 (54.2) | ||||
Ki-67 LI | ||||||||
Low | 62 | 26 (41.9) | 36 (58.1) | −0.803 | 0.422 | −0.073 | 0.424 | |
High | 61 | 30 (49.2) | 31 (50.8) | |||||
MVD | ||||||||
Low | 61 | 19 (31.1) | 42 (68.9) | −2.813 | 0.005 | −0.249 | 0.004 | |
High | 68 | 38 (55.9) | 30 (44.1) | |||||