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Fig. 3 | Cancer Cell International

Fig. 3

From: Bone morphogenetic protein 2 (BMP2) induces growth suppression and enhances chemosensitivity of human colon cancer cells

Fig. 3

BMP2 regulated multiple cellular processes in HCT116 cells. a Hierarchical clustering of BMP2 HCT116 vs LV control HCT116 cells based on differentially expressed mRNA levels. Each column represents one replica and each row represents a transcript. Expression level of each gene in a single sample is depicted according to the colour scale. b Pie chart illustrating the distribution of the top 10 pathway designations for the differentially expressed genes in BMP2 HCT116 cells. The pie size corresponds to the number of matched entities. c The cell cycle pathway is illustrated in panel c. d The expression levels of selected genes from the microarray data were validated using qRT-PCR in BMP2 HCT116 cells. Data are presented as mean ± S.D, n = 3

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