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Fig. 4 | Cancer Cell International

Fig. 4

From: Bone morphogenetic protein 2 (BMP2) induces growth suppression and enhances chemosensitivity of human colon cancer cells

Fig. 4

BMP2 sensitize CRC cells to 5-fluorouracil. a Illustration of the DNA damage response pathway based on microarray data with matched entities highlighted. b Representative fluorescence images of BMP2 and LV control HCT116 cells [±different concentration (1.5–100 μM) 5-fluorouracil]. Cells were stained with acridine orange/ethidium bromide to detect apoptotic (cells with green condensed chromatin) and necrotic cells (red) c. Representative clonogenic assay showing reduced clonogenicity of BMP2 HCT116 compared to LV control HCT116 cells (±1.5 μM 5-fluorouracil). Plates were stained with Diff-Quik stain set on day 10

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