Fig. 1

Patterns of NCC migration in zebrafish. Schematic cartoon depicting the two main migratory pathways of NCCs during embryonic development (transverse section of a vertebrate embryo). NCCs (blue) follow the ventromedial pathway (green arrow) and migrate between the neural tube and somites and then bilaterally reach the dorsal portion of the dorsal aorta, where they differentiate into sympathoadrenal progenitors (green). NCCs that migrate dorsolaterally (red arrow) between somites and the overlying ectodermal epithelium give rise to pigment cells (red). NCCs neural crest cells, EE ectodermal epithelium, NT neural tube, NO notochord, DA dorsal aorta, S somite