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Fig. 4 | Cancer Cell International

Fig. 4

From: RETRACTED ARTICLE: Overexpression of A613T and G462T variants of DNA polymerase β weakens chemotherapy sensitivity in esophageal cancer cell lines

Fig. 4

Sensitivity of cell lines to cisplatin and 5-FU. a A613T and G462T mutations weaken the proliferation inhibition effect of 5-FU. Concentration of 5-FU was 0 to 50 μg/mL. b A613T and G462T mutations weaken the proliferation inhibition effect of cisplatin. Concentration of cisplatin was 0 to 8 μg/mL. WT: wild-type EC9706 cells; A613T: A613T mutation EC9706 cells; G462T: G462T mutation EC9706 cells; polβ−/−: polβ null EC9706 cells (*P < 0.05)

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Cancer Cell International

ISSN: 1475-2867

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