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Table 2 Mutations in 538 EC patients

From: RETRACTED ARTICLE: Overexpression of A613T and G462T variants of DNA polymerase β weakens chemotherapy sensitivity in esophageal cancer cell lines

Gene variation n Proportion % Amino acid variation Domain
375 nt: A → G 21 3.90 88 aa: I → V 8kD domain
454 nt: T → C 19 3.53 114 aa: F → S Thumb domain
462 nt: G → T 12 2.23 117 aa: E → termination mutation Thumb domain
466 nt: G → A 32 5.95 118 aa: G → E Thumb domain
613 nt: A → T 18 3.35 167 aa: K → I Palm domain
648 nt: G → C 20 3.72 179 aa: G → R Palm domain
660 nt: A → G 27 5.02 183 aa: R → G Palm domain
665 nt: T → C 8 1.49 184 aa: G → G Palm domain
676 nt: G → A 15 2.79 188 aa: S → N Palm domain
737 nt: A → T 6 1.12 208 aa: P → P Palm domain
740 nt: A → G 9 1.67 209 aa: K → K Palm domain
832 nt: A → G 11 2.04 240 aa: Q → R Palm domain
853 nt: A → G 7 1.30 247 aa: E → G Palm domain
854nt: A → C, and 855nt: A → C 12 2.23 247 aa: E → D, and 248 aa: K → Q Palm domain
177–234 nt: deletion 12 2.23 22 aa: frameshift mutation;
26 aa: termination mutation
8kD domain
Total 229 42.57
  1. GenBank Acc# M13140.1