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Fig. 10 | Cancer Cell International

Fig. 10

From: Inhibition of integrin β3, a binding partner of kallistatin, leads to reduced viability, invasion and proliferation in NCI-H446 cells

Fig. 10

The proposed effect sites of kallistatin through integrin signaling pathway. Kallistatin inhibited the both of PI3 K/AKT and Erk/MAPK resulted in a downregulation of Bcl-2 expression for the anti-apoptotic homologs, and an upregulation for the pro-apoptotic homologs, and inhinited the phosphorylation integrin β3 and suppresses the expression of Grb2 for the cell migration

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Cancer Cell International

ISSN: 1475-2867

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