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Fig. 3 | Cancer Cell International

Fig. 3

From: Inhibition of integrin β3, a binding partner of kallistatin, leads to reduced viability, invasion and proliferation in NCI-H446 cells

Fig. 3

Integrin β3 is involved in the effects of kallistatin on viability of NCI-H446 cells. a Integrin β3 expression in NCI-H446 cells was downregulated by siRNA in a time-dependent manner that was analyzed by immunoblotting (N = 3). Housekeeping proteins GAPDH are useful as loading controls for immunoblotting and protein normalization. The data are expressed as mean ± SD from three independent experiments. *P < 0.05. b Inhibition effect of kallistatin on the viability of NCI-H446 cells was attenuated by treatment of siRNA. N = 6×3 for each group. N.C siRNA was used as negative control, respectively. *P < 0.05, #P < 0.05, # comparison of the differences between column 2 and 3 and between column 4 and 5. b Inhibition effect of kallistatin on the viability of NCI-H446 cells was attenuated by antibody against integrin β3. N = 6 × 3 for each group. Mouse IgG were used as negative control. *P < 0.05, #P < 0.05, # comparison of the differences between column 2 and 3 and between column 4 and 5

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