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Fig. 7 | Cancer Cell International

Fig. 7

From: Inhibition of integrin β3, a binding partner of kallistatin, leads to reduced viability, invasion and proliferation in NCI-H446 cells

Fig. 7

Kallistatin inhibits integrin β3-mediated PI3-K/AKT pathwaysignaling. a and e Using 200 μg total cellular proteins from each of the samples for immunoblotting analysis. The protein levels were normalized with β-actin. a Phosphorylation of AKT Erk1/2 and PI3 K were inhibited in a time-dependent manner without detectable change of their total AKT and Erk1/2 protein levels after treated with kallistatin (N = 3). (bd) The relative levels of PI3 K, phosphorylated AKT and phosphorylated Erk1/2 proteins were calculated and plotted. The data are expressed as mean ± SD from three independent experiments (N = 3). *P < 0.05. f The relative levels of Grb2 proteins were calculated and plotted. The data are expressed as mean ± SD from three independent experiments (N = 3). *P < 0.05

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