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Table 1 The IC50 index and water solubility of betulin derivatives evaluated for human Me45 cells

From: Anticancer properties of ester derivatives of betulin in human metastatic melanoma cells (Me-45)

Compound IC50 for Me45 cells [µM] Water solubility
24 h 48 h 72 h
Betulin‐lLys‐NH2 55.339 20.275 2.456 Very good
Betulin‐lOrn‐NH2 70.658 27.155 2.465 Very good
Betulin‐l ‐Dab‐NH2 66.453 51.405 9.253 Very good
Betulin‐lDap‐NH2 107.740 61.524 75.489 Very good
Betulin‐l ‐Ala‐NH2 86.573 62.089 10.125 Very good
Betulin 24.208 42.822 30.456 Weak
Betulinic acid 22.772 22.794 15.325 Middle