Table 1 The IC50 index and water solubility of betulin derivatives evaluated for human Me45 cells
From: Anticancer properties of ester derivatives of betulin in human metastatic melanoma cells (Me-45)
Compound | IC50 for Me45 cells [µM] | Water solubility | ||
|---|---|---|---|---|
24 h | 48 h | 72 h | ||
Betulin‐l‐Lys‐NH2 | 55.339 | 20.275 | 2.456 | Very good |
Betulin‐l‐Orn‐NH2 | 70.658 | 27.155 | 2.465 | Very good |
Betulin‐l ‐Dab‐NH2 | 66.453 | 51.405 | 9.253 | Very good |
Betulin‐l‐Dap‐NH2 | 107.740 | 61.524 | 75.489 | Very good |
Betulin‐l ‐Ala‐NH2 | 86.573 | 62.089 | 10.125 | Very good |
Betulin | 24.208 | 42.822 | 30.456 | Weak |
Betulinic acid | 22.772 | 22.794 | 15.325 | Middle |