Table 2 Meta-analysis of the CYP2E1 gene polymorphisms on breast cancer risk
From: Role of CYP2E1 polymorphisms in breast cancer: a systematic review and meta-analysis
Comparison | Population | No. of studies | Test of association | Mode | Heterogeneity | ||
|---|---|---|---|---|---|---|---|
OR (95% CI) | P value | I2 (%) | P value | ||||
rs2031920 C>T | |||||||
T vs. C | Overall | 3 | 0.91 (0.75–1.10) | 0.317 | F | 0.0 | 0.380 |
T/T vs. C/C | Overall | 3 | 0.87 (0.27–2.87) | 0.821 | R | 64.0 | 0.096 |
C/T vs. C/C | Overall | 3 | 0.94 (0.76–1.16) | 0.549 | F | 0.0 | 0.414 |
T/T + C/T vs. C/C | Overall | 3 | 0.92 (0.75–1.13) | 0.434 | F | 0.0 | 0.447 |
T/T vs. C/T + C/C | Overall | 3 | 0.87 (0.26–2.89) | 0.825 | R | 64.3 | 0.094 |
CYP2E1*5 Rsa I/Pst I (c1/c2) | |||||||
c2 vs. c1 | Overall | 4 | 0.97 (0.80–1.17) | 0.718 | F | 45.9 | 0.136 |
Asian | 3 | 0.96 (0.80–1.16) | 0.693 | F | 63.5 | 0.065 | |
c2/c2 vs. c1/c1 | Overall | 4 | 0.74 (0.42–1.30) | 0.300 | F | 49.7 | 0.137 |
Asian | 3 | 0.74 (0.82–1.30) | 0.300 | F | 49.7 | 0.137 | |
c1/c2 vs. c1/c1 | Overall | 4 | 1.03 (0.81–1.29) | 0.797 | F | 40.8 | 0.167 |
Asian | 3 | 1.31 (0.74–2.34) | 0.823 | F | 60.3 | 0.080 | |
c2/c2 + c1/c2 vs. c1/c1 | Overall | 4 | 1.00 (0.80–1.24) | 0.994 | F | 44.4 | 0.145 |
Asian | 3 | 1.00 (0.80–1.24) | 0.965 | F | 62.6 | 0.069 | |
c2/c2 vs. c1/c2 + c1/c1 | Overall | 4 | 0.75 (0.43–1.30) | 0.303 | F | 48.0 | 0.146 |
Asian | 3 | 0.75 (0.43–1.30) | 0.303 | F | 48.0 | 0.146 | |
CYP2E1*6 Dra I (D/C) | |||||||
C vs. D | Overall | 4 | 1.28 (1.05–1.55) | 0.014 | F | 0.0 | 0.532 |
Caucasian | 2 | 1.32 (1.06–1.64) | 0.014 | F | – | – | |
C/C vs. D/D | Overall | 4 | 1.47 (0.75–2.91) | 0.266 | F | 0.0 | 0.667 |
Caucasian | 2 | 1.66 (0.68–4.09) | 0.268 | F | – | – | |
D/C vs. D/D | Overall | 4 | 1.29 (1.04–1.61) | 0.023 | F | 0.0 | 0.667 |
Caucasian | 2 | 1.32 (1.04–1.68) | 0.025 | F | – | – | |
C/C + D/C vs. D/D | Overall | 4 | 1.25 (1.04–1.51) | 0.019 | F | 0.0 | 0.724 |
Caucasian | 2 | 1.26 (1.02–1.55) | 0.032 | F | 18.0 | 0.269 | |
C/C vs. D/D + D/C | Overall | 4 | 1.39 (0.71–2.72) | 0.339 | F | 0.0 | 0.654 |
Caucasian | 2 | 1.58 (0.64–3.89) | 0.318 | F | – | – | |