Regulation of the hypoxic tumor environment in hepatocellular carcinoma using RNA interference

Table 1 Up regulation of tumor angiogenic factors under hypoxia

Factors	Functions	Ref
VEGF	Increased vascular permeability	[5]
	Endothelial sprouting	[36]
	EC proliferation and migration	[10, 35]
	EC assembly	[40]
iNO	Increased vascular permeability	[35]
Angiopoietin-2	Endothelial sprouting	[36]
PDGF	Pericyte recruting	[9, 56]
PDGF	EC proliferation and migration	[3, 40]
MMPs	Degradation of extracellular matrix	[5]
Tie2	Form the blood vessels	[40]
TGF-beta	Increased EC differentiation formation of vascular structure	[35, 40]
TGF-beta	Formed vascular structure	[10, 40]
VEGFR2	Stimulate endothelial cell mitogenesis and cell migration	[3, 10]
VEGFR2	Enhances microvascular permeability	[5, 56]
Endothelin	Regulates local vascular tone and integrity	[10, 40]
Endothelin	Influences EC growth and survival	[5]
IL-8	Increased vascular permeability	[5]
	EC proliferation and migration	[25]
	Endothelial sprouting	[36]

ISSN: 1475-2867