Fig. 3

The down-regulations of Trkb, E-cadherin and β-catenin activation were detected in MG-63 cells treated with celecoxib (50, 100 µmol/l), cisplatin (10 µg/ml), and the combination for 48 h. Significant down-regulations of Trkb, E-cadherin and β-catenin activation were observed in MG-63 cells treated with cisplatin and celecoxib (100 µmol/l). However, the potentialization of celecoxib (50 µmol/l) and cisplatin was not demonstrated. β-actin was used as an equal loading control