Fig. 6From: Celecoxib enhances anticancer effect of cisplatin and induces anoikis in osteosarcoma via PI3K/Akt pathwayA hypothetical model for PI3K and COX-2 pathway interaction. Celecoxib down-regulates the expression of PI3K/Akt, which plays an essential role in the regulation of MDR1, MRP1, BCRP and Trkb, E-cadherin, β-catenin, eventually causing anoikis. PI3K activity negatively regulates expression of COX-2Back to article page