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Fig. 4 | Cancer Cell International

Fig. 4

From: Overexpression of trefoil factor 3 (TFF3) contributes to the malignant progression in cervical cancer cells

Fig. 4

TFF3 regulates cell and invasion of cervical cancer cells through activation of the STAT3/CDH1 signaling pathway. a Capacity of SiHa and Hela cells with either forced or depleted expression of TFF3 to penetrate to EHS Matrigel and Quantification analysis. b Western blot analysis was used to assess the levels of CDH1, p-STAT3 andSTAT3 in cervical cancer cells with either forced or depleted expression of TFF3. c Effect of CDH1-specific siRNA on invasion of SIHA or HELA with depleted expression of TFF3. CDH1-specific siRNA increased the invasive percentage SiHa and Hela cells with depleted expression of TFF3. d Western blot analysis was used to assess the levels of CDH1 in SiHa or Hela cells with forced expression of TFF3on exposure to JSI-124 (0.2 μM) inhibitor and Effect of p-STAT3 on invasion of SiHa or Hela. Statistical significance was assessed by using an unpaired two-tailed Student’s t test (P < 0.05 was considered as significant) using SPSS 18.0. Columns are the mean of triplicate experiments; bars ±SD. **P < 0.001

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