Paradoxes of the EphB1 receptor in malignant brain tumors

Table 1 Summary of EphB1/ephrins functions in part of tissues and cell lines

Tissue and cell	Tissue and cell type	Expression	EphB1 functions	Ligand-dependent	Refs.
CNS^a	Normal CNS tissue	Positive	Involved in synapse formation in the hippocampus	Dependent	[13]
CNS	Normal CNS tissue	Positive	Involved in neurogenesis of neural progenitors	Dependent	[16]
CNS	Normal CNS tissue	Positive	Involved in rerouting RGCb projections	Dependent	[17]
CNS	Normal CNS tissue	Positive	Increases expression of Nurr1	Dependent	[18–20]
P19	Embryonic carcinoma cell	Positive	Promotes cell growth and migration	Dependent	[50]
U87	Glioma cell	Undetectable	Inhibits cell migration and invasion after overexpression	Dependent	[26]
U251	Glioma cell	Undetectable	Inhibits cell migration and invasion after overexpression	Dependent	[26]
Daoy	Medulloblastoma	Overexpressed	Promotes cell growth and migration	Unknown	[48–51]
HEK 293T	Stable cell line expressing ephrin-B1	Overexpressed	Induces the activation of C-Jun N-terminal kinase activation	Dependent	[44]
U87	Glioma cells transfected with ephrin-B2	Overexpressed	Stimulates the migration and invasion	Unknown	[41]
Striatal anlage	Normal CNS tissue	Positive	Involved in the migration of two sets of neurons	Dependent	[25]
CNS	Normal CNS tissue	Positive	Regulates the proliferation and migration of neural progenitors	Dependent	[16]

ISSN: 1475-2867