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Table 1 Summary of EphB1/ephrins functions in part of tissues and cell lines

From: Paradoxes of the EphB1 receptor in malignant brain tumors

Tissue and cell Tissue and cell type Expression EphB1 functions Ligand-dependent Refs.
CNSa Normal CNS tissue Positive Involved in synapse formation in the hippocampus Dependent [13]
CNS Normal CNS tissue Positive Involved in neurogenesis of neural progenitors Dependent [16]
CNS Normal CNS tissue Positive Involved in rerouting RGCb projections Dependent [17]
CNS Normal CNS tissue Positive Increases expression of Nurr1 Dependent [1820]
P19 Embryonic carcinoma cell Positive Promotes cell growth and migration Dependent [50]
U87 Glioma cell Undetectable Inhibits cell migration and invasion after overexpression Dependent [26]
U251 Glioma cell Undetectable Inhibits cell migration and invasion after overexpression Dependent [26]
Daoy Medulloblastoma Overexpressed Promotes cell growth and migration Unknown [4851]
HEK 293T Stable cell line expressing ephrin-B1 Overexpressed Induces the activation of C-Jun N-terminal kinase activation Dependent [44]
U87 Glioma cells transfected with ephrin-B2 Overexpressed Stimulates the migration and invasion Unknown [41]
Striatal anlage Normal CNS tissue Positive Involved in the migration of two sets of neurons Dependent [25]
CNS Normal CNS tissue Positive Regulates the proliferation and migration of neural progenitors Dependent [16]
  1. aRepresents central nervous system
  2. bRepresents retinal ganglion cell