Fig. 8

Effect of miR-335 on cell cycle distribution and apoptosis in SGC-7901 cells. a Representative histograms depicting cell cycle profiles of 5-aza-treated and untreated SGC-7901 cells. The cell cycle was significantly arrested in G0/G1 phase by up-regulating miR-335 in SGC-7901 cells. b Proportions of cells in various phases of the cell cycle. Results are means of five independent experiments ± SD. *P < 0.05 between groups. c Representative histograms depicting apoptosis of 5-aza-treated and untreated SGC-7901 cells. Representative graph demonstrating increased apoptosis rate in SGC-7901 cells treated with 5-aza compared with negative control cells. d Average apoptotic rate of five independent experiments ± SD are shown. **P < 0.01 between groups