Up-regulation of CRKL by microRNA-335 methylation is associated with poor prognosis in gastric cancer

Table 1 The correlation between expression levels of miR-335 in GC specimens and GC clinicopathologic features

	Low expression (n = 115)		High expression (n = 116)		P
	n	%	n	%	P
Age					0.728
>55	87	76	90	78
≤55	28	24	26	22
Sex					0.641
Male	63	55	60	52
Female	52	45	56	48
Histological grade					0.616
Well	39	34	43	37
Poor	76	66	73	63
Tumor size (cm)					0.030*
≤3.5	24	21	39	34
>3.5	91	79	77	66
Macroscopic type					0.702
Early stage	3	3	3	3
Borrmann I + II	10	9	14	12
Borrmann III + IV	102	88	99	85
Lauren's grade					0.813
Intestinal	36	31	38	33
Diffuse	79	69	78	67
Venous invasion					0.027*
Absent	81	70	96	83
Present	34	30	20	17
Liver metastasis					0.669
Absent	105	91	104	90
Present	10	9	12	10
Peritoneal dissemination					0.027*
Absent	95	83	107	92
Present	20	17	9	8
pT stage					0.040*
T1	1	1	5	4
T2	20	17	24	21
T3	30	26	42	36
T4	64	56	45	39
pN stage					0.038*
N0 + N1	29	25	44	38
N2 + N3	86	75	72	62
Metastasis lymph node					0.033*
Negative	26	23	41	35
Positive	89	77	75	65
Invasion into lymphatic vessels					0.041*
Negative	87	76	100	86
Positive	28	24	16	14
AJCC stage					0.005*
I + II	48	42	70	60
III + IV	67	58	46	40

ISSN: 1475-2867