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Table 2 Association between the promoter region methylation status of miR-335 and clinicopathologic features in patients with gastric cancer

From: Up-regulation of CRKL by microRNA-335 methylation is associated with poor prognosis in gastric cancer

  Hypermethylation (n = 127) Hypomethylation (n = 104) P
n % n %  
Age      0.830
 >55 98 77 79 76  
 ≤55 29 23 25 24  
Sex      0.371
 Male 71 56 52 50  
 Female 56 44 52 50  
Histological grade      0.765
 Well 44 35 38 37  
 Poor 83 65 66 63  
Tumor size (cm)      0.004*
 ≤3.5 25 20 38 37  
 >3.5 102 80 66 63  
Macroscopic type      0.843
 Early stage 4 3 2 2  
 Borrmann I + II 13 10 11 11  
 Borrmann III + IV 110 87 91 87  
Lauren's grade      0.347
 Intestinal 44 35 30 29  
 Diffuse 83 65 74 71  
Venous invasion      0.922
 Absent 97 76 80 77  
 Present 30 24 24 23  
Liver metastasis      0.622
 Absent 116 91 93 89  
 Present 11 9 11 11  
Peritoneal dissemination      0.223
 Absent 108 85 94 90  
 Present 19 15 10 10  
pT stage      0.434
 T1 3 2 3 3  
 T2 23 18 21 20  
 T3 35 28 37 36  
 T4 66 52 43 41  
pN stage      0.240
 N0 + N1 36 28 37 36  
 N2 + N3 91 72 67 64  
Metastasis lymph node      0.058
 Negative 30 24 37 35  
 Positive 97 76 67 65  
Invasion into lymphatic vessels      0.001*
 Negative 93 73 94 90  
 Positive 34 27 10 10  
AJCC stage      0.197
 I + II 60 47 58 56  
 III + IV 67 53 46 44  
MiR-335 level      <0.001*
 Low expression 78 61 37 36  
 High expression 49 39 67 64  
  1. Based on Pearson χ 2 test and Fisher exact test
  2. pT primary tumor, pN primary node, AJCC American Joint Committee on Cancer
  3. * Statistically significant