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Fig. 3 | Cancer Cell International

Fig. 3

From: Establishment and characterization of a novel highly aggressive gallbladder cancer cell line, TJ-GBC2

Fig. 3

High expression of epithelial or epithelial tumor marker of TJ-GBC2 cell line in vitro and in vivo. a Epithelial tumor markers of the culture supernatant of TJ-GBC2 cells in vitro. Supernatant CA19-9 (>1000 vs. 2.86 U/ml, normal value: <39 U/ml) and AFP (65.85 vs. 0.20 ng/ml, normal value: <4.7 n/ml) levels were higher than those of pure growth medium (all P = 0.000); but CEA showed normal levels (0.61 vs. 0.61 ng/ml, P > 0.05; normal value: <7 ng/ml). b Expression of characteristic epithelial and mesenchymal cell markers in the xenografts of nude mice in vivo. Epithelial marker CK7, CK8, CK19 and E-cadherin were positively expressed in the xenografts, with positive p53 expression in few cells and negative mesenchymal marker vimentin expression, which is in accord with the results of primary tumor of human GBC

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