Table 2 Genotype distributions and allele frequencies of RAGE polymorphisms between cases and controls
Model | Controls (N = 207) | Cancer (N = 200) | Adjusted OR (95% CI)a | P |
|---|---|---|---|---|
rs2070600 | ||||
GG | 136 (0.657) | 113 (0.565) | 1.00ref | |
AG | 58 (0.280) | 72 (0.360) | 1.62 (1.03–2.58) | 0.038 |
AA | 13 (0.063) | 15 (0.075) | 1.27 (0.54–2.98) | 0.581 |
A allele | 84 (0.203) | 102 (0.255) | 1.00ref | |
G allele | 330 (0.797) | 298 (0.745) | 1.37 (0.96–1.95) | 0.082 |
AG + AA vs. GG | 1.56 (1.01–2.39) | 0.044 | ||
AA vs. AG + GG | 1.09 (0.47–2.51) | 0.841 | ||
rs184003 | ||||
GG | 138 (0.667) | 148 (0.740) | 1.00ref | |
GT | 64 (0.309) | 48 (0.240) | 0.62 (0.39–0.99) | 0.048 |
TT | 5 (0.024) | 4 (0.020) | 1.02 (0.24–4.27) | 0.984 |
G allele | 340 (0.821) | 344 (0.860) | 1.00ref | |
T allele | 74 (0.179) | 56 (0.140) | 0.72 (0.48–1.08) | 0.107 |
GT + TT vs. GG | 0.64 (0.41–1.02) | 0.060 | ||
TT vs. GT + GG | 1.15 (0.28–4.81) | 0.849 | ||
rs1800624 | ||||
TT | 166 (0.802) | 150 (0.750) | 1.00ref | |
AT | 35 (0.169) | 42 (0.210) | 1.40 (0.83–2.39) | 0.210 |
AA | 6 (0.029) | 8 (0.040) | 1.03 (0.32–3.35) | 0.961 |
T allele | 367 (0.886) | 342 (0.855) | 1.00ref | |
A allele | 47 (0.114) | 58 (0.145) | 1.25 (0.81–1.94) | 0.319 |
AA + AT vs. TT | 1.34 (0.82–2.21) | 0.246 | ||
AA vs. AT + TT | 0.97 (0.30–3.12) | 0.952 | ||
rs1800625 | ||||
CC | 1 (0.005) | 3 (0.015) | 1.00ref | |
CT | 22 (0.106) | 13 (0.065) | 0.25 (0.02–2.97) | 0.275 |
TT | 184 (0.889) | 184 (0.920) | 0.44 (0.04–4.70) | 0.500 |
C allele | 24 (0.058) | 19 (0.048) | 1.00ref | |
T allele | 390 (0.942) | 381 (0.953) | 1.33 (0.69–2.54) | 0.393 |
TT + CT vs. CC | 0.42 (0.04–4.45) | 0.473 | ||
TT vs. CT + CC | 1.52 (0.75–3.08) | 0.245 | ||