Fig. 3
From: Screening of breast cancer stem cell inhibitors using a protein kinase inhibitor library
Effects of protein kinase inhibitors on the mammosphere formation. a EGFRK, PKC, CAMKII, MLCK, JAK-3, IKK, and GSK-3β inhibitors significantly decrease the mammosphere-forming efficiency (MFE) at the concentrations of 5 or 10 μM. In particular, the CAMKII (E4), JAK-3 (G4), and IKK (G5) inhibitors demonstrate >50% inhibition of MFE at 5 μM. b The inhibitory effect of CAMKII (E4), JAK-3 (G4), and IKK (G5) inhibitors on MFE is also observed in secondary and tertiary mammosphere assay. Representative images with quantitation bar are shown (scale bar 100 μm). *p < 0.05 vs. each control