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Table 1 Summary of protein kinase inhibitors suppressing mammosphere formation

From: Screening of breast cancer stem cell inhibitors using a protein kinase inhibitor library

Number Name Targets Inhibitory activity Number Name Targets Inhibitory activity
B1 PD-98059 MEK Negative C1 Tyrphostin 46 EGFRK, PDGFRK Negative
B2 U-0126 MEK Negative C2 Tyrphostin 47 EGFRK Negative
B3 SB-203580 p38 MAPK Negative C3 Tyrphostin 51 EGFRK Negative
B4 H-7 2HCl PKA, PKG, MLCK, PKC Negative C4 Tyrphostin 1 Negative control for tyrosine kinase Negative
B5 H-9 HCl PKA, PKG, MLCK, PKC Negative C5 Tyrphostin AG 1288 Tyrosine kinases Negative
B6 Staurosporine Pan-specific Negative C6 Tyrphostin AG 1478 EGFRK Positive
B7 AG-494 EGFRK, PDGFRK Negative C7 Tyrphostin AG1295 Tyrosine kinases Negative
B8 AG-825 HER1-2 Negative C8 Tyrphostin 9 PDGFRK Negative
B9 Lavendustin A EGFRK Negative C9 Hydroxy-2-naphthalenyl methylphosphonic acid IRK Negative
B10 RG-1462 EGFRK Negative C10 PKC-412 PKC inhibitor Negative
B11 Tyrphostin 23 EGFRK Negative C11 Piceatannol Syk negative
B12 Tyrphostin 25 EGFRK Negative C12 PP1 Src family Negative
D1 AG-490 JAK-2 Negative E1 HA-1004 2HCl PKA, PKG Negative
D2 AG-126 IRAK Negative E2 HA-1077 2HCl PKA, PKG Negative
D3 AG-370 PDGFRK Negative E3 2-Hydroxy-5-(2,5-dihydroxy benzyl amino) benzoic acid EGFRK, CaMK II Negative
D4 AG-879 NGFRK Negative E4 KN-62 CaMK II Positive
D5 LY 294002 PI 3-K Negative E5 KN-93 CaMK II Positive
D6 Wortmannin PI 3-K Negative E6 ML-7 HCl MLCK Positive
D7 GF 109203X PKC Negative E7 ML-9 HCl MLCK Negative
D8 Hypericin PKC Negative E8 2-Aminopurine p58 PITSLRE beta1 Negative
D9 Ro 31-8220 mesylate PKC Positive E9 N9-isopropyl-olomoucine CDK Negative
D10 d-Erythro-Sphingosine PKC Positive E10 Olomoucine CDK Negative
D11 H-89 2HCl PKA, Negative E11 Iso-olomoucine Negative control for olomoucine Negative
D12 H-8 PKA, PKG Negative E12 Roscovitine CDK Negative
F1 5-Iodotubericidin ERK2, CK1, CK2 Positive G1 Erbstatin analog EGFRK Negative
F2 LFM-A13 BTK Negative G2 Quercetin 2H2O PI 3-K Negative
F3 SB-202190 p38 MAPK Negative G3 SU1498 Flk1 Negative
F4 PP2 Src family Negative G4 ZM 449829 JAK-3 Positive
F5 ZM 336372 cRAF Negative G5 BAY 11-7082 IKK pathway Positive
F6 SU 4312 Flk1 Negative G6 5,6-dichloro-1-β-d-ribofuranosylbenzimidazole CK II Negative
F7 AG-1296 PDGFRK Negative G7 2,2′,3,3′,4,4′-Hexahydroxy-1,1′-biphenyl-6,6′dimethanol dimethyl ether PKC alpha, PKC gamma Negative
F8 GW 5074 cRAF Negative G8 SP 600125 JNK Negative
F9 Palmitoyl-d l-carnitine PKC Negative G9 Indirubin GSK-3beta, CDK5 Negative
F10 Rottlerin PKC delta Positive G10 Indirubin-3′-monooxime GSK-3beta Positive
F11 Genistein Tyrosine kinases Negative G11 Y-27632 2HCl ROCK Negative
F12 Daidzein Negative control for genistein Negative G12 Kenpaullone GSK-3beta Negative
H2 Triciribine Akt signaling Negative H6 Apigenin CK-II Negative
H3 BML-257 Akt Negative H7 BML-265 EGFRK Negative
H4 SC-514 IKK2 Negative H8 Rapamycin mTOR Negative
H5 BML-259 Cdk5/p25 Negative