Synthetic curcumin derivative DK1 possessed G2/M arrest and induced apoptosis through accumulation of intracellular ROS in MCF-7 breast cancer cells

Table 2 The values of IC₅₀ of DK1 in MCF-7, MDA-MB231 and MCF-10A

Cell lines	24 h		48 h		72 h
Cell lines	DK1 (µM)	Curcumin (µM)	DK1 (µM)	Curcumin (µM)	DK1 (µM)	Curcumin (µM)
HL-60	137.61 ± 2.16	57.01 ± 3.75	123.85 ± 3.27	29.86 ± 3.11	73.39 ± 2.65	21.72 ± 1.76
HepG2	>150 ± 5.85	67.86 ± 2.88	137.61 ± 4.13	40.72 ± 2.76	64.22 ± 3.12	24.43 ± 2.25
MCF-7	96.83 ± 4.87	40.72 ± 3.24	33.33 ± 3.50	36.58 ± 2.31	25.00 ± 3.71	30.15 ± 2.36
MDA-MB-231	104.17 ± 5.23	35.29 ± 4.16	45.83 ± 4.66	21.72 ± 1.87	37.50 ± 4.82	21.72 ± 3.18
MCF-10A	>208	190.02 ± 3.67	125.83 ± 3.67	114.01 ± 3.57	104.17 ± 5.21	100.44 ± 3.17
Selective index of MCF-10A/MCF-7	>2.17	4.67	3.75	3.50	4.17	3.33
Selective index of MCF-10A/MDA	>2.00	5.38	2.72	5.25	2.77	4.63

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