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Table 2 The values of IC50 of DK1 in MCF-7, MDA-MB231 and MCF-10A

From: Synthetic curcumin derivative DK1 possessed G2/M arrest and induced apoptosis through accumulation of intracellular ROS in MCF-7 breast cancer cells

Cell lines 24 h 48 h 72 h
DK1 (µM) Curcumin (µM) DK1 (µM) Curcumin (µM) DK1 (µM) Curcumin (µM)
HL-60 137.61 ± 2.16 57.01 ± 3.75 123.85 ± 3.27 29.86 ± 3.11 73.39 ± 2.65 21.72 ± 1.76
HepG2 >150 ± 5.85 67.86 ± 2.88 137.61 ± 4.13 40.72 ± 2.76 64.22 ± 3.12 24.43 ± 2.25
MCF-7 96.83 ± 4.87 40.72 ± 3.24 33.33 ± 3.50 36.58 ± 2.31 25.00 ± 3.71 30.15 ± 2.36
MDA-MB-231 104.17 ± 5.23 35.29 ± 4.16 45.83 ± 4.66 21.72 ± 1.87 37.50 ± 4.82 21.72 ± 3.18
MCF-10A >208 190.02 ± 3.67 125.83 ± 3.67 114.01 ± 3.57 104.17 ± 5.21 100.44 ± 3.17
Selective index of MCF-10A/MCF-7 >2.17 4.67 3.75 3.50 4.17 3.33
Selective index of MCF-10A/MDA >2.00 5.38 2.72 5.25 2.77 4.63