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Fig. 9 | Cancer Cell International

Fig. 9

From: Dual roles of extracellular signal-regulated kinase (ERK) in quinoline compound BPIQ-induced apoptosis and anti-migration of human non-small cell lung cancer cells

Fig. 9

The possible model for the roles of ERK in BPIQ-induced apoptosis and anti-migration of lung cancer cells. Sustainable ERK or overexpression are thought to promote cellular proliferation and survival in cancer cells. However, the activation of ERK may involve sensitizing cancer cells to BPIQ, eventually induce the apoptosis of NSCLC cells. It will benefit regulation of ERK-dependent apoptosis of cancer cells which highly express ERK. On the contrary, low dose (sub-IC50) of BPIQ exerts the anti-migration of NSCLC cells through downregulating the activation of SP-1 transcription factor and its downstream such as COX and MMP activity. In future, low dose of BPIQ combining ERK inhibitors such as PD98059 may be a promising strategy for chemoprevention or anti-metastasis of NSCLC cells

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