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Fig. 5 | Cancer Cell International

Fig. 5

From: MicroRNA-338-3p suppresses cell proliferation and induces apoptosis of non-small-cell lung cancer by targeting sphingosine kinase 2

Fig. 5

miR-338-3p inhibits subcutaneous tumor growth. NSCLC A549 and H1299 cell line stably expressing luciferase infected by lentivirus packaged with vectors LV6-miR-338-3p or LV6 empty vector as described in “Methods”. Live images of tumors were measured every 3 days for 4 weeks and monitored with bioluminescent imaging. Thirty minutes after cell injection, luciferase substrate was added (150 mg/kg) and luciferase activity was measured every 5 days using the same protocol. Data are mean ± SD (*p < 0.05, t test). a Representative images of tumors on indicated days (left panel) and tumor growth curve in mice are shown (right panel) for A549 cells. b Representative images of tumors on indicated days (left panel) and tumor growth curve in mice (right panel) for H1299 cells

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