Fig. 3

PD98059 (25 µM) inhibits spontaneous and BBR (100 µM) -induced ERK phorphorylation (a), and partially blocks BBR-inhibited cell proliferation (b). All experiments were repeated 3 times (n = 3). All data are shown as mean ± SEM (error bars), (*p < 0.05; **p < 0.01 vs control), (^# p < 0.05 vs. BBR 100 μM)