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Fig. 4 | Cancer Cell International

Fig. 4

From: Suppression of endothelial cell migration by tumor associated macrophage-derived exosomes is reversed by epithelial ovarian cancer exosomal lncRNA

Fig. 4

Exosomal miR-146b-5p targets the TRAF6 gene of endothelial cells. A luciferase reporter revealed that miR-146b-5p that could regulate TRAF6 expression. a, b Combinations of predicted miRNA recognition sites (MREs) for each putative target transcript of miR-146b-5p were cloned into the luciferase reporter vector and transfected into HUVECs along with the indicated miRNA mimics. The mean ± SD of three independent experiments is shown, and statistical significance is indicated by *(P < 0.05). c, d The expression of TRAF6, measured by qRT-PCR and Western blots, was significantly suppressed by the addition of exosomes derived from TAMs or the mimics of hsa-miR-146b-5p

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