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Fig. 5 | Cancer Cell International

Fig. 5

From: Suppression of endothelial cell migration by tumor associated macrophage-derived exosomes is reversed by epithelial ovarian cancer exosomal lncRNA

Fig. 5

Regulation of TRAF6 expression and the related signaling pathway by TAM-derived exosomes. a, b TRAF6 gene silencing efficiency of EC cells by siTRAF6-1 and siTRAF6-2. c, d TRAF6 depletion by siTRAF6-1 and siTRAF6-2 reduced the migration of HUVECs. The mean ± SD of three independent experiments is shown, and statistical significance is indicated by *(P < 0.05). e A representative immunoblot of TRAF6, phosphorylated(p-)NF-κB, total NF-κB, phosphorylated(p-)IκBα, total IκBα, and MMP-2 in HUVECs treated with TAM-derived exosomes, miR-146b-5p mimics, or siTRAF6

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