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Table 1 Gene ontology analysis of aberrantly methylated-differentially expressed genes in colorectal cancer

From: Aberrantly methylated-differentially expressed genes and pathways in colorectal cancer

Category GO analysis Term Gene count % P value
Hypomethylation and high expression
  GOTERM_BP_FAT GO:0009611~response to wounding 37 9.00 9.44E−08
  GOTERM_BP_FAT GO:0006954~inflammatory response 25 6.08 3.48E−06
  GOTERM_BP_FAT GO:0008283~cell proliferation 29 7.06 7.95E−06
  GOTERM_BP_FAT GO:0007155~cell adhesion 37 9.00 5.54E−05
  GOTERM_BP_FAT GO:0022610~biological adhesion 37 9.00 5.55E−05
  GOTERM_CC_FAT GO:0005576~extracellular region 92 22.38 2.01E−08
  GOTERM_CC_FAT GO:0044421~extracellular region part 55 13.38 3.78E−08
  GOTERM_CC_FAT GO:0005615~extracellular space 42 10.22 4.12E−07
  GOTERM_CC_FAT GO:0005578~proteinaceous extracellular matrix 21 5.11 2.45E−04
  GOTERM_CC_FAT GO:0005625~soluble fraction 20 4.87 5.01E−04
  GOTERM_MF_FAT GO:0042802~identical protein binding 35 8.52 8.25E−05
  GOTERM_MF_FAT GO:0005125~cytokine activity 15 3.65 6.69E−04
  GOTERM_MF_FAT GO:0004175~endopeptidase activity 21 5.11 2.33E−03
  GOTERM_MF_FAT GO:0030674~protein binding, bridging 9 2.19 3.39E−03
  GOTERM_MF_FAT GO:0008201~heparin binding 9 2.19 5.90E−03
Hypermethylation and low expression
  GOTERM_BP_FAT GO:0007267~cell–cell signaling 29 12.13 3.32E−07
  GOTERM_BP_FAT GO:0019226~transmission of nerve impulse 18 7.53 4.70E−05
  GOTERM_BP_FAT GO:0031644~regulation of neurological system process 11 4.60 1.72E−04
  GOTERM_BP_FAT GO:0007610~behavior 20 8.37 1.90E−04
  GOTERM_BP_FAT GO:0030182~neuron differentiation 19 7.95 2.35E−04
  GOTERM_CC_FAT GO:0044459~plasma membrane part 64 26.78 2.13E−09
  GOTERM_CC_FAT GO:0005886~plasma membrane 84 35.15 5.38E−07
  GOTERM_CC_FAT GO:0043005~neuron projection 19 7.95 1.13E−06
  GOTERM_CC_FAT GO:0005887~integral to plasma membrane 38 15.90 1.67E−06
  GOTERM_CC_FAT GO:0031226~intrinsic to plasma membrane 38 15.90 2.85E−06
  GOTERM_MF_FAT GO:0003700~transcription factor activity 38 15.90 2.48E−07
  GOTERM_MF_FAT GO:0022836~gated channel activity 16 6.69 9.15E−05
  GOTERM_MF_FAT GO:0015267~channel activity 18 7.53 2.17E−04
  GOTERM_MF_FAT GO:0022803~passive transmembrane transporter activity 18 7.53 2.23E−04
  GOTERM_MF_FAT GO:0005216~ion channel activity 17 7.11 3.17E−04