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Table 2 KEGG pathway analysis of aberrantly methylated-differentially expressed genes in colorectal cancer

From: Aberrantly methylated-differentially expressed genes and pathways in colorectal cancer

Pathway ID Pathway name Gene no. % P value Genes
Hypomethylation and high expression
 hsa04060 Cytokine–cytokine receptor interaction 20 4.87 5.86E−04 CXCL1, IL2RA, LTBR, CXCL3, IL21R, CXCL2, MET, CXCL9, TNFSF15, TNFRSF4, CCL18, LIF, INHBA, TNFRSF9, TNFSF11, IL23A, PRLR, CCL20, IL20RA, ACVR1
 hsa04115 p53 signaling pathway 8 1.95 5.54E−03 CCND1, SERPINB5, CD82, RRM2, TSC2, CASP8, PMAIP1, ATM
 hsa04110 Cell cycle 9 2.19 0.045 CCND1, PKMYT1, PRKDC, RB1, CDC16, CDC27, ATM, WEE1, TFDP1
Hypermethylation and low expression
 hsa04020 Calcium signaling pathway 12 5.02 7.80E−04 EGFR, EDNRB, ADCY2, PTGER3, PDE1B, PDE1C, DRD5, GRIN2A, PLCD1, ITPKB, CAMK2B, PTGFR
 hsa04950 Maturity onset diabetes of the young 5 2.09 1.45E−03 HHEX, NEUROD1, HNF4G, NEUROG3, NKX2-2
 hsa04514 Cell adhesion molecules (CAMs) 8 3.35 0.017 NCAM1, CD8A, ITGA8, NLGN4X, CNTN1, ITGA4, JAM2, HLA-G
 hsa04080 Neuroactive ligand-receptor interaction 11 4.60 0.033 EDNRB, SSTR2, PTGER3, GABRB3, GRIK1, GRIK2, DRD5, GRIN2A, GRIA3, PTGFR, VIPR2
 hsa04062 Chemokine signaling pathway 9 3.77 0.035 DOCK2, ADCY2, CXCL14, TIAM1, HCK, PIK3CD, CCR10, RAP1A, ELMO1
 hsa04666 Fc gamma R-mediated phagocytosis 6 2.51 0.043 DOCK2, HCK, PIK3CD, ARF6, AMPH, DNM2