TY - JOUR AU - Fu, Qiang AU - Liu, Pengruofeng AU - Sun, Xiumei AU - Huang, Shanshan AU - Han, Fengchan AU - Zhang, Lili AU - Xu, Yannan AU - Liu, Tingyan PY - 2017 DA - 2017/09/05 TI - Ribonucleic acid interference knockdown of IL-6 enhances the efficacy of cisplatin in laryngeal cancer stem cells by down-regulating the IL-6/STAT3/HIF1 pathway JO - Cancer Cell International SP - 79 VL - 17 IS - 1 AB - Cisplatin has been used in the treatment of many cancers, including laryngeal cancer; however, its efficacy can be reduced due to the development of drug resistance. This study aimed to investigate whether interleukin-6 (IL-6) knockdown may enhance the efficacy of cisplatin in laryngeal cancer stem cells (CSC) and the potential involvement of the signal transducer and activator of transcription 3 (STAT3) and hypoxia-inducible factor 1 (HIF1) in this effect. SN - 1475-2867 UR - https://doi.org/10.1186/s12935-017-0448-0 DO - 10.1186/s12935-017-0448-0 ID - Fu2017 ER -