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Fig. 2 | Cancer Cell International

Fig. 2

From: Ribonucleic acid interference knockdown of IL-6 enhances the efficacy of cisplatin in laryngeal cancer stem cells by down-regulating the IL-6/STAT3/HIF1 pathway

Fig. 2

The siRNA-IL-6 knockdown reduced IL-6, STAT3 and HIF1 mRNA (ac) and protein (dg) levels in hep2-CSC. As compared with that of the corresponding mRNA of controls in hep2-CSC, IL-6, STAT3 and HIF1 mRNA levels were significantly decreased in the siRNA-IL-6 group (p < 0.05). The empty vector control group also showed diminished levels of IL-6, STAT3 and HIF1 mRNA. GAPDH served as a house-keeping gene. Similarly, IL-6, STAT3 and HIF1 protein levels were reduced significantly after siRNA-IL-6 treatment. Actin was used to normalize protein levels. ***p < 0.001 vs hep2-CSC control: ###p < 0.001 vs siRNA-IL-6 vector control

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