Fig. 1

SNP rs3202538 in ERBB3 3′UTR of GC patients with GT/TT genotype can up-regulate of ERBB3 transcription by deregulated by miR-211 and miR-204. a Bioinformatics predicted the binding site of the miR-204, miR-211 and miR-4287 with ErbB3 and the mutation types were conducted into the pGL3 plasmid as presented. b Cells were cotransfected with miR-204, miR-211 and miR-4287 mimics or control, Renilla luciferase vector pRL-SV40 for 48 h. Both firefly and Renilla luciferase activities were measured in the same sample. Firefly luciferase signals were normalized with Renilla luciferase signals. Data were presented as the mean ± SEM. Asterisk indicates a significant difference (P < 0.05)