The prognostic values of the expression of Vimentin, TP53, and Podoplanin in patients with cervical cancer

Lin, Jiaying; Lu, Jiaqi; Wang, Chao; Xue, Xiaohong

doi:10.1186/s12935-017-0450-6

Cancer Cell International

Table 2 Correlation of immunohistochemical study of Vimentin, TP53 and Podoplanin with clinicopathological factors in cervical cancer

From: The prognostic values of the expression of Vimentin, TP53, and Podoplanin in patients with cervical cancer

Characteristics	Total (n = 130)	Vimentin (n = 130)		Chi square test P value	Fisher’s exact test P value	P53 (n = 130)		Chi square test P value	Fisher’s exact test P value	Podoplanin (n = 130)		Chi square test P value	Fisher’s exact test P value
Characteristics	Total (n = 130)	Positive (n = 35)	Negative (n = 95)	Chi square test P value	Fisher’s exact test P value	Positive (n = 26)	Negative (n = 104)	Chi square test P value	Fisher’s exact test P value	Positive (n = 61)	Negative (n = 69)	Chi square test P value	Fisher’s exact test P value
Age at diagnosis (years)
<50	77	14	63	0.007	0.009	12	65	0.129	0.098	21	56	<0.0001	<0.0001
≥50	53	21	32			14	39			40	13
Tumor size (cm)
<4	100	24	76	0.17	0.24	16	84	0.037	0.038	44	56	0.223	0.297
≥4	30	11	19			10	20			17	13
Histological grades
Well/moderate	108	27	81	0.273	0.297	24	84	0.16	0.243	48	60	0.21	0.246
Poor	22	8	14			2	20			13	9
FIGO stage
Ia1–Ib2	89	22	67	0.404	0.265	16	73	0.396	0.266	38	51	0.155	0.187
IIa1–IIa2	41	13	28			10	31			23	18
Lymph node metastasis
No	108	24	84	0.007	0.015	21	87	0.726	0.771	46	62	0.028	0.035
Yes	22	11	11			5	17			15	7
Vascular space involvement
No	73	18	55	0.51	0.554	6	67	<0.0001	<0.0001	13	60	<0.0001	<0.0001
Yes	57	17	40			20	37			48	9
Tumor histology
Squamous	95	25	70	0.416	0.486	23	72	0.108	0.126	46	49	0.165	0.171
AC/ASC	29	7	22			3	26			12	17
Others	6	3	3			0	6			3	3
Lymphatic invasion
Yes	57	21	36	0.024	0.029	10	47	0.536	0.347	52	5	<0.0001	<0.0001
No	73	14	59			16	57			9	64
Squamous cell carcinoma antigen, ng/ml
≤5	88	23	65	0.77	0.834	16	72	0.453	0.487	54	34	0.841	0.85
>5	42	12	30			10	32			25	17
Deep stromal invasion
Yes	69	21	48	0.337	0.429	17	52	0.16	0.191	40	29	0.007	0.009
No	61	14	47			9	52			21	40
Positive parametrium
Yes	10	2	8	0.607	0.464	3	7	0.411	0.418	8	2	0.029	0.045
No	120	33	87			23	97			53	67
Positive surgical margin
Yes	3	1	2	0.8	0.613	1	2	0.559	0.491	3	0	0.247	0.338
No	127	34	93			25	102			58	69
Vaginal involvement
Yes	32	8	24	0.778	0.486	8	24	0.415	0.449	18	14	0.223	0.308
No	98	27	71			18	80			43	55
Recurrence
Yes	15	12	3	<0.001	<0.001	7	8	0.006	0.012	12	3	0.006	0.011
No	115	23	92			19	96			49	66
Vital status (at follow-up)
Alive	120	27	93	<0.001	<0.001	20	100	0.001	0.004	52	68	0.004	0.006
Dead	10	8	2			6	4			9	1
Ki67 (%) (mean ± SD)	53.3 ± 30.5	49.7 ± 31.2	62.4 ± 26.3	0.037		50.9 ± 32.1	61.2 ± 21.9	0.059		32.6 ± 34.1	41.1 ± 36.1	0.171

AC adenocarcinoma, ASC adenosquamous carcinoma, others including undifferentiated sarcoma, neuroendocrine and glassy cell cervical carcinoma

Back to article page

ISSN: 1475-2867

Contact us

General enquiries: journalsubmissions@springernature.com