Fig. 1From: Dual EGFR and BRAF blockade overcomes resistance to vemurafenib in BRAF mutated thyroid carcinoma cellsVemurafenib partially inhibits cell proliferation, cell cycle progression and ERK signaling in BRAF V600E thyroid carcinoma cell lines. a, b Growth rate (a) and cell viability (b) in BRAF V600E BHT101, FRO and BCPAP thyroid carcinoma cell lines and BRAF-wild type WRO cells treated with 1 and 10 μM PLX4032. c Cell cycle distribution in BRAF V600E BHT101, FRO and BCPAP thyroid carcinoma cell lines and BRAF-wild type WRO cells exposed to 10 μM PLX4032 for 15 h. a–c Statistical significance respect to each untreated control: *p < 0.05; **p < 0.005; ***p < 0.0005. d ERK and phosphoERK immunoblot analysis in BRAF V600E BHT101, FRO and BCPAP thyroid carcinoma cell lines and BRAF-wild type WRO cells exposed to 10 μM PLX4032 for 1 hBack to article page