Fig. 6

The effects of miR-485-5p/NUDT1 axis on normal gastric cells. a Quantitative RT-PCR analysis of miR-485-5p levels in GES-1 cells transfected with miR-485-5p mimics or inhibitors. b Relative NUDT1 mRNA levels after transfection. c The regulation of NUDT1 expression by miR-485-5p. d–f The up-regulation of miR-485-5p had no effect on the proliferation (d) and migration (e, f) of GES-1 cells, whereas the knockdown of miR-485-5p could promote malignant phenotype. *P < 0.05; **P < 0.01