Fig. 5

Effects of crocetin and cisplatin on PI3K/AKT pathways in KYSE-150 cells. The expression levels of p-PI3K, PI3K, p-AKT, and AKT in KYSE-150 cells were untreated (control) or treated with 200 μmol/L of crocetin, 2 μg/L of cisplatin (DDP), and 200 μmol/L of crocetin + 2 μg/L of cisplatin (C + D) for 48 h, as determined by Western blot analysis. GAPDH was used as loading control. *p < 0.05 compared with the control group; ^#p < 0.05 compared with the combined crocetin and cisplatin group